Integrated approaches for the toxicological risk assessment of cosmetic ingredients & products based on regulatory guidelines

An integrated approach, which combines in silico pre-screening with in vitro testing, is employed for a swift and efficient evaluation of cosmetic and chemical toxicity risks. These innovative methods contribute to a faster and more cost-effective toxicological risk assessment compared to traditional testing methods.
In silico pre-screening is based on OECD guidelines for toxicological risk assessement of substances:

• Acute toxicity
• Skin permeability, irritation/corrosion & sensitization
• Endocrine disrupting chemicals
• Photo-induced toxicity
• Genotoxicity/carcinogenicity
  In vitro testing is based on OECD guidelines for toxicological risk assessement of substances:
• Skin Absorption (OECD 428)
• Skin Irritation (OECD 439)
• In vitro Skin Sensitization: DPRA, KeratinoSens, h-CLAT (OECD 442C/D/E)
• Skin Corrosion (OECD 435)
• In vitro 3T3 NRU Phototoxicity (OECD432)
• Ocular irritation (OECD 496)
• Genototoxicity: Ames test, micronucleus assay (OECD 471/487)